Sodium Carbonate → p-Aminopropiophenone
反応式
[C:1]([C:5]1[CH:14]=[CH:13][C:8]([NH:9]C(=O)C)=[CH:7][CH:6]=1)(=[O:4])[CH2:2][CH3:3].C(=O)([O-])[O-].[Na+].[Na+]>Cl>[C:1]([C:5]1[CH:6]=[CH:7][C:8]([NH2:9])=[CH:13][CH:14]=1)(=[O:4])[CH2:2][CH3:3]参加物
4
実験手順
141 g (1 mole) of p-propionylacetanilide were dissolved while refluxing and stirring into 600 ml of 5 N hydrochloric acid. Refluxing was continued for 30 min, cooling was applied, and sodium carbonate (about 300 g) was added, until the reaction mixture was alkaline. The residue formed was sucked off, washed with water until neutral and recrystallized from 725 ml of isopropanol. The mixture was sucked off and washed with ether. After drying under vacuum, a yellow-brownish powder was obtained.
後処理
- temperaturewhile refluxing
- temperatureRefluxing
- temperaturecooling
- customThe residue formed
- washwashed with water until neutral and
- customrecrystallized from 725 ml of isopropanol
- washwashed with ether
- customAfter drying under vacuum
- customa yellow-brownish powder was obtained
出典と根拠
- ORDレコード
- ord-dddf784d330f4a969843da8cb504e923
- 出典データセット
- uspto-grants-1980_05
- 特許番号
- US04202697
反応ノート
読み込み中…