Hydrazine → (Adamant-1-ylmethyl)hydrazine hydrochloride

HRID 1395183

反応式

HRID 1395183 の反応式
[NH2:1][NH2:2].[Cl:3][CH2:4][C:5]12[CH2:14][CH:9]3[CH2:10][CH:11]([CH2:13][CH:7]([CH2:8]3)[CH2:6]1)[CH2:12]2.[OH-].[Na+]>CO.O>[ClH:3].[C:5]12([CH2:4][NH:1][NH2:2])[CH2:14][CH:9]3[CH2:10][CH:11]([CH2:13][CH:7]([CH2:8]3)[CH2:6]1)[CH2:12]2

参加物

6

反応物 3

HCID 9321HydrazineHCID 14798Sodium HydroxideHCID 21039691-(Chloromethyl)adamantane

生成物 1

HCID 20340449(Adamant-1-ylmethyl)hydrazine hydrochloride収率 38.4%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

4.0 g (120 mmol) of anhydrous hydrazine and 2.3 g (12 mmol) of 1-chloromethyladamantane were introduced into a sealable tube under nitrogen atmosphere. The tube was sealed and heated at 150° for 16 hours. After cooling to room temperature the contents were suspended in methanol, treated with a solution 0.5 g of sodium hydroxide in 1.5 ml of water, and the volatiles removed in vacuo. The resulting solid was extracted with ether and the solution dried with magnesium sulfate and treated with hydrogen chloride to give 1 g of the title compound (38% yield).

後処理

  1. customThe tube was sealed
  2. temperatureheated at 150° for 16 hours
  3. customthe volatiles removed in vacuo
  4. extractionThe resulting solid was extracted with ether
  5. dry with materialthe solution dried with magnesium sulfate
  6. additiontreated with hydrogen chloride

出典と根拠

ORDレコード
ord-d19c0c7c64f745719d8f55933f50ae2d
出典データセット
uspto-grants-1980_05
特許番号
US04202892

関連ノート

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