Hydrogen Peroxide → 1-[3-(p-Tert.amyl-phenyl)-2-methyl-propyl]-piperidine-1-oxide

HRID 1395210ノート

反応式

HRID 1395210 の反応式
[OH:1]O.[C:3]([C:8]1[CH:13]=[CH:12][C:11]([CH2:14][CH:15]([CH3:23])[CH2:16][N:17]2[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]2)=[CH:10][CH:9]=1)([CH2:6][CH3:7])([CH3:5])[CH3:4]>C(O)(C)C.[Pt]>[C:3]([C:8]1[CH:9]=[CH:10][C:11]([CH2:14][CH:15]([CH3:23])[CH2:16][N+:17]2([O-:1])[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22]2)=[CH:12][CH:13]=1)([CH2:6][CH3:7])([CH3:4])[CH3:5]

参加物

5

反応物 2

HCID 784Hydrogen Peroxide2 回HCID 190989441-[3-(p-Tert.amyl-phenyl)-2-methyl-propyl]-piperidine

生成物 1

HCID 203405661-[3-(p-Tert.amyl-phenyl)-2-methyl-propyl]-piperidine-1-oxide

試薬・触媒・溶媒 2

HCID 23939Platinum触媒HCID 3776Isopropanol溶媒

反応条件

温度
40 °C

実験手順

7.2 g of 30% hydrogen peroxide are added dropwise at 40° C. to a solution of 5.8 g of 1-[3-(p-tert.amyl-phenyl)-2-methyl-propyl]-piperidine in 20 ml of isopropanol and this addition is repeated after 24 hours. After stirring at 40° C. for 60 hours, the mixture is cooled and the excess hydrogen peroxide is decomposed by addition of platinum sponge. The solution is filtered, the filtrate is evaporated, the residue is taken up in 50 ml of water and extracted with hexane. The aqueous solution is subsequently evaporated and the residue is dried in a high vacuum. There is obtained pure 1-[3-(p-tert.amyl-phenyl)-2-methyl-propyl]-piperidine-1-oxide; nD20 =1.5180.

後処理

  1. additionthis addition
  2. temperaturethe mixture is cooled
  3. filtrationThe solution is filtered
  4. customthe filtrate is evaporated
  5. extractionextracted with hexane
  6. customThe aqueous solution is subsequently evaporated
  7. customthe residue is dried in a high vacuum

出典と根拠

ORDレコード
ord-5ff15de35f5145cc8cea553fe2009f56
出典データセット
uspto-grants-1980_05
特許番号
US04202894

反応ノート

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