Propargylamine → 1-Nitro-2-(2-propynylamino)-2-{2-[(5-methylaminomethyl-2-furyl)methylthio]ethylamino}ethylene

HRID 1395380ノート

反応式

HRID 1395380 の反応式
[N+:1]([CH:4]=[C:5](SC)[NH:6][CH2:7][CH2:8][S:9][CH2:10][C:11]1[O:12][C:13]([CH2:16][NH:17][CH3:18])=[CH:14][CH:15]=1)([O-:3])=[O:2].[CH2:21]([NH2:24])[C:22]#[CH:23]>C(#N)C>[N+:1]([CH:4]=[C:5]([NH:24][CH2:21][C:22]#[CH:23])[NH:6][CH2:7][CH2:8][S:9][CH2:10][C:11]1[O:12][C:13]([CH2:16][NH:17][CH3:18])=[CH:14][CH:15]=1)([O-:3])=[O:2]

参加物

4

反応物 2

HCID 239041PropargylamineHCID 705383981-Nitro-2-methylthio-2-{2-[(5-methylaminomethyl-2-furyl)methylthio]ethylamino}ethylene

生成物 1

HCID 867369881-Nitro-2-(2-propynylamino)-2-{2-[(5-methylaminomethyl-2-furyl)methylthio]ethylamino}ethylene

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A mixture of 1-nitro-2-methylthio-2-{2-[(5-methylaminomethyl-2-furyl)methylthio]ethylamino}ethylene [prepared according to the procedure described in Belgian Pat. No. 857,388] and propargylamine in acetonitrile is stirred and heated under a positive pressure of nitrogen to give, after workup and chromatography, the title compound.

後処理

  1. customprepared
  2. temperatureheated under a positive pressure of nitrogen
  3. customto give

出典と根拠

ORDレコード
ord-28cbf161f2b347a1aec3b99d783a71d6
出典データセット
uspto-grants-1980_05
特許番号
US04203909

反応ノート

読み込み中…