Hydrochloric Acid → HCID 20339419、化合物

HRID 1395459ノート

反応式

HRID 1395459 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][N:9]1[CH2:23][CH2:22][N:12]2[C:13]3[C:18]([NH:19][C:20](=[O:21])[CH:11]2[CH2:10]1)=[CH:17][CH:16]=[CH:15][CH:14]=3.O.Cl.[H][H]>O=[Pt]=O.C(O)C>[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[CH2:7][CH2:8][N:9]1[CH2:23][CH2:22][N:12]2[C:13]3[C:18]([NH:19][C:20](=[O:21])[CH:11]2[CH2:10]1)=[CH:17][CH:16]=[CH:15][CH:14]=3

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 203394222,3,4,4a-Tetrahydro-3-[2-(2-Pyridinyl)Ethyl]-1H-Pyrazino[1,2-a]Quinoxalin-5(6H)-OneHCID 178418361HCID 178418361、化合物

生成物 1

HCID 20339419HCID 20339419、化合物

試薬・触媒・溶媒 2

HCID 345198Adams' catalyst触媒HCID 702Ethanol溶媒

実験手順

A solution of 2,3,4,4a-tetrahydro-3-[2-(2-pyridinyl)-ethyl]-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one in 120 ml. water and 60 ml. ethanol containing 14 ml. conc. hydrochloric acid, was shaken with 1.2 g. of PtO2 under 45 psi. hydrogen pressure. Solution was filtered, concentrated under vacuum, and residue crystallized once from ethanol and then from methanol. After filtration and drying the dihydrochloride salt of the title compound had a m.p. of 268°-271° C. (dec.); yield: 3.5 g.

後処理

  1. filtrationSolution was filtered
  2. concentrationconcentrated under vacuum, and residue
  3. customcrystallized once from ethanol
  4. filtrationAfter filtration
  5. dry with materialdrying the dihydrochloride salt of the title compound

出典と根拠

ORDレコード
ord-b8dec87d938f4455b1c7ac8511c4e605
出典データセット
uspto-grants-1980_05
特許番号
US04203987

反応ノート

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