N-(2-Dimethylaminoethyl)-N-(5-methyl-2-pyridyl)acetamide → 2-(2-Dimethylaminoethylamino)-5-methylpyridine

HRID 1395524ノート

反応式

HRID 1395524 の反応式
[CH3:1][N:2]([CH3:16])[CH2:3][CH2:4][N:5]([C:9]1[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][N:10]=1)C(=O)C>[OH-].[Na+]>[CH3:1][N:2]([CH3:16])[CH2:3][CH2:4][NH:5][C:9]1[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][N:10]=1

参加物

3

反応物 1

HCID 20339535N-(2-Dimethylaminoethyl)-N-(5-methyl-2-pyridyl)acetamide

生成物 1

HCID 203395792-(2-Dimethylaminoethylamino)-5-methylpyridine

試薬・触媒・溶媒 1

HCID 14798Sodium Hydroxide溶媒

実験手順

To N-(2-dimethylaminoethyl)-N-(5-methyl-2-pyridyl) acetamide (50.0 g, 0.226 mole) is added 200 ml of 5 N sodium hydroxide. The mixture is stirred rapidly at reflux for 16 hours. The mixture is cooled and the oil is extracted into ether. The ether extract is dried and evaporated under reduced pressure. Distillation of the residue gives a pale yellow liquid, b.p. 105°-112°, n25D 1.5355. Weight obtained is 35 g.

後処理

  1. temperatureat reflux for 16 hours
  2. temperatureThe mixture is cooled
  3. extractionthe oil is extracted into ether
  4. extractionThe ether extract
  5. customis dried
  6. customevaporated under reduced pressure
  7. distillationDistillation of the residue
  8. customgives a pale yellow liquid, b.p. 105°-112°, n25D 1.5355
  9. customWeight obtained

出典と根拠

ORDレコード
ord-1718d04284554ea89fa4944c7c42e1c9
出典データセット
uspto-grants-1980_05
特許番号
US04203988

反応ノート

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