Ethylene Oxide → 2-[Benzyl(2-hydroxyethyl)amino]benzamide

HRID 1395804ノート

反応式

HRID 1395804 の反応式
[CH2:1]([NH:8][C:9]1[CH:17]=[CH:16][CH:15]=[CH:14][C:10]=1[C:11]([NH2:13])=[O:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:18]1[O:20][CH2:19]1>C(O)(=O)C>[CH2:1]([N:8]([CH2:18][CH2:19][OH:20])[C:9]1[CH:17]=[CH:16][CH:15]=[CH:14][C:10]=1[C:11]([NH2:13])=[O:12])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 6354Ethylene OxideHCID 11345158HCID 11345158、化合物

生成物 1

HCID 203383632-[Benzyl(2-hydroxyethyl)amino]benzamide

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

o-Benzylaminobenzamide (62 g) was added to a cold solution of 85 ml ethylene oxide in 500 ml acetic acid, the mixture stirred 22 hours at room temperature and concentrated on the rotovap to remove 250 ml acetic acid. The remainder was made alkaline with 10% NaOH and the solid filtered washed with water and recrystallized from 300 ml ethyl acetate to give 48.5 g. product, m. 133-7.

後処理

  1. concentrationconcentrated on the rotovap
  2. customto remove 250 ml acetic acid
  3. filtrationthe solid filtered
  4. washwashed with water
  5. customrecrystallized from 300 ml ethyl acetate
  6. customto give 48.5 g

出典と根拠

ORDレコード
ord-eea9a560cead4d6395ea84d6a9a4e48c
出典データセット
uspto-grants-1980_05
特許番号
US04205173

反応ノート

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