Dichloromethane → (3R,3aR,6R,6aR)-6-(5-fluoro-2-nitro-phenoxy)-3-methoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan

To 0.9 g (3.0 mmol) (3R,3aR,6R,6aR)-6-(5-fluoro-2-nitro-phenoxy)-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-ol (III.1), 0.1 g (0.3 mmol) tetrabutylammonium iodide and 1.3 ml (7.8 mmol) of a 6 mol/l aqueous NaOH solution in 15 ml DCM 0.3 ml (3.6 mmol) dimethyl sulfate are added dropwise and the mixture is stirred at RT for 24 h. Additional 1.3 ml (7.8 mmol) of a aqueous 6 mol/l NaOH solution and 0.3 ml (3.6 mml) dimethyl sulfate are added and the mixture is stirred at RT over night. The reaction mixture is washed with water, dried and evaporated. The residue is purified by FC.

1. stirringthe mixture is stirred at RT over night
2. washThe reaction mixture is washed with water
3. customdried
4. customevaporated
5. customThe residue is purified by FC

ORDレコード

ord-803fb7a6fb5a4665a0a1720f0942ccd3

出典データセット

uspto-grants-2014_12

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08901138B2