Sulfuric Acid → HCID 58575197、化合物

HRID 1396658ノート

反応式

HRID 1396658 の反応式
[F:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([CH2:12][O:13][CH3:14])[CH:3]=1.S(=O)(=O)(O)O.[N+:20]([O-])([O-:22])=[O:21].[K+]>>[F:1][C:2]1[C:11]([N+:20]([O-:22])=[O:21])=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([CH2:12][O:13][CH3:14])[CH:3]=1

参加物

4

反応物 3

HCID 1118Sulfuric AcidHCID 24434Potassium NitrateHCID 21075354HCID 21075354、化合物

生成物 1

HCID 58575197HCID 58575197、化合物収率 87.1%

反応条件

温度
-10 °C

実験手順

To a mixture of 1.75 g of methyl 4-fluoro-2-(methoxymethyl)benzoate and 8.7 mL of concentrated sulfuric acid was added 964 mg of potassium nitrate over 5 minutes under cooling at −10° C. After stirring at the same temperature for 4 hours and a half, the reaction mixture was added to 300 mL of ice water, followed by stirring. The solid was collected by filtration, washed with water, and dried under reduced pressure to obtain 1.87 g of methyl 4-fluoro-2-(methoxymethyl)-5-nitrobenzoate.

後処理

  1. stirringby stirring
  2. filtrationThe solid was collected by filtration
  3. washwashed with water
  4. customdried under reduced pressure

出典と根拠

ORDレコード
ord-3a9e0ac0ad8b41f99fa272fcd0846e4b
出典データセット
uspto-grants-2014_12
特許番号
US08901126B2

反応ノート

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