Water → 1-[(2-Propen-1-yloxy)carbonyl]-3-pyrazolidinecarboxylic acid

HRID 1396914ノート

反応式

HRID 1396914 の反応式
[N:1]1([C:20]([O:22][CH2:23][CH:24]=[CH2:25])=[O:21])[CH2:5][CH2:4][CH:3]([C:6]([O:8]C(C)(C)C)=[O:7])[N:2]1C(OC(C)(C)C)=O.C(O)(C(F)(F)F)=O.O>ClCCl>[CH2:23]([O:22][C:20]([N:1]1[CH2:5][CH2:4][CH:3]([C:6]([OH:8])=[O:7])[NH:2]1)=[O:21])[CH:24]=[CH2:25]

参加物

5

反応物 3

HCID 962WaterHCID 6422Trifluoroacetic acidHCID 867063572,3-Bis(1,1-dimethylethyl) 1-(2-propen-1-yl) 1,2,3-pyrazolidinetricarboxylate

生成物 1

HCID 682879411-[(2-Propen-1-yloxy)carbonyl]-3-pyrazolidinecarboxylic acid収率 100%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

2,3-Bis(1,1-dimethylethyl) 1-(2-propen-1-yl) 1,2,3-pyrazolidinetricarboxylate (1.2 g, 3.37 mmol) was dissolved in dichloromethane (DCM) (6.63 ml) under N2 at ambient temperature. TFA (15.56 ml, 202 mmol) and water (1.820 ml, 101 mmol) were added in one portion. The reaction was stirred at ambient temperature for 3 days. The solvent was removed under reduced pressure to give crude 1-[(2-propen-1-yloxy)carbonyl]-3-pyrazolidinecarboxylic acid (0.674 g, 3.37 mmol, 100% crude yield). MS (ES+) m/z 201.0 (MH+).

後処理

  1. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-a0f779dd189e4988b1cc95625c56a12b
出典データセット
uspto-grants-2014_12
特許番号
US08901119B2

反応ノート

読み込み中…