HCID 178445896、化合物 → HCID 178445908、化合物
反応式
[CH:1]([N:3]([CH2:12][C@@H:13]([CH2:41][CH2:42][CH2:43][CH3:44])[C:14]([N:16]1[C@H:20]([C:21]([NH:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][N+:25]=2[O-:30])=[O:22])[CH2:19][CH2:18][N:17]1C(OCC1C=CC=CC=1)=O)=[O:15])[O:4]CC1C=CC=CC=1)=[O:2]>CCO.[OH-].[OH-].[Pd+2]>[CH:1]([N:3]([CH2:12][C@@H:13]([CH2:41][CH2:42][CH2:43][CH3:44])[C:14]([N:16]1[C@H:20]([C:21]([NH:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][N+:25]=2[O-:30])=[O:22])[CH2:19][CH2:18][NH:17]1)=[O:15])[OH:4])=[O:2]参加物
4
実験手順
To a solution of phenylmethyl (3S)-2-[(2R)-2-({formyl[(phenylmethyl)oxy]amino}methyl)hexanoyl]-3-{[(1-oxido-2-pyridinyl)amino]carbonyl}-1-pyrazolidinecarboxylate (85 mg, 0.14 mmol) in EtOH (15 mL) was added Pd(OH)2/C (30 mg). The mixture was degassed and placed under H2 atmosphere for 1 h at rt. The catalyst was filtered off and the filtrate was concentrated. The residue was purified by pre-HPLC to provide the titled compound (22 mg, 40%). LCMS: (M+H)+: 380.2.