HCID 68181592、化合物 → 1-Methyl-3-hydroxypyridine-2-one

HRID 1398522

反応式

HRID 1398522 の反応式
C([O:8][C:9]1[C:10](=[O:16])[N:11]([CH3:15])[CH:12]=[CH:13][CH:14]=1)C1C=CC=CC=1.[H][H]>[Pd].CO>[OH:8][C:9]1[C:10](=[O:16])[N:11]([CH3:15])[CH:12]=[CH:13][CH:14]=1

参加物

5

反応物 2

HCID 68181592HCID 68181592、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 880261-Methyl-3-hydroxypyridine-2-one

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A mixture of 3-(benzyloxy)-1-methyl-1H-pyridin-2-one (23 g, 106.85 mmol) and 10% palladium on carbon (2.3 g) in methanol (250 mL) was stirred under 1 atmosphere of hydrogen for 5 hr at room temperature. The catalyst was removed by filtration. The filtrate was concentrated in vacuo to give the title compound (12 g (90%) as a purple solid: 1H NMR (400 MHz, DMSO) delta 8.96 (s, 1H), 7.15-7.13 (m, 1H), 6.70-6.68 (m, 1H), 6.07 (t, J=7.0 Hz, 1H), 3.47 (s, 3H).

後処理

  1. customThe catalyst was removed by filtration
  2. concentrationThe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-d3995e6565174daeafa09f81f8fa05c1
出典データセット
uspto-grants-2014_12
特許番号
US08901313B2

関連ノート

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