Sodium Bicarbonate → HCID 178434210、化合物
反応式
[Br:1][C:2]1[C:7]([F:8])=[CH:6][C:5](/[C:9](=[N:11]/[NH2:12])/[CH3:10])=[C:4](F)[CH:3]=1.C([O-])(O)=O.[Na+]>C(O)CO>[Br:1][C:2]1[CH:3]=[C:4]2[C:5]([C:9]([CH3:10])=[N:11][NH:12]2)=[CH:6][C:7]=1[F:8]参加物
4
実験手順
A solution of (E)-[1-(4-bromo-2,5-difluorophenyl)ethylidene]hydrazine in ethylene glycol (3 mL) was heated at 165° C. for 3 hours in a sealed tube. The mixture was cooled to RT and saturated NaHCO3 was added (3 mL) and stirred for 10 minutes. The mixture was filtered and solid was washed with water (5 mL×2) to obtain the desired product brown solid (163 mg, 62%).
後処理
- filtrationThe mixture was filtered
- washsolid was washed with water (5 mL×2)
出典と根拠
- ORDレコード
- ord-f98666d4f79246418018fbf0d9bcad77
- 出典データセット
- uspto-grants-2014_12
- 特許番号
- US08901313B2
反応ノート
読み込み中…