反応式
Br[C:2]1[CH:3]=[CH:4][C:5]2[N:9]=[C:8]([O:10][CH:11]3[CH2:14][O:13][CH2:12]3)[N:7]([C:15]3[CH:20]=[CH:19][N:18]=[C:17]([NH2:21])[N:16]=3)[C:6]=2[CH:22]=1.[CH3:23][C:24]([OH:28])([C:26]#[CH:27])[CH3:25]>>[NH2:21][C:17]1[N:16]=[C:15]([N:7]2[C:6]3[CH:22]=[C:2]([C:27]#[C:26][C:24]([CH3:25])([OH:28])[CH3:23])[CH:3]=[CH:4][C:5]=3[N:9]=[C:8]2[O:10][CH:11]2[CH2:14][O:13][CH2:12]2)[CH:20]=[CH:19][N:18]=1参加物
3
実験手順
The title compound was prepared by the method described in Example 142-b, by reacting 4-[6-bromo-2-(oxetan-3-yloxy)-1H-1,3-benzodiazol-1-yl]pyrimidin-2-amine with 2-methyl-3-butyn-2-ol: 1H NMR (DMSO, 500 MHz) delta 1.46 (6H, s), 4.73 (2H, dd, J=7.9, 4.9 Hz), 4.94 (2H, t, J=7.1 Hz), 5.40 (1H, s), 5.94-5.68 (1H, m), 7.17-6.99 (3H, m), 7.21 (1H, dd, J=8.2, 1.6 Hz), 7.41 (1H, d, J=8.2 Hz), 8.14 (1H, d, J=1.0 Hz), 8.39 (1H, d, J=5.5 Hz); LC-MS: m/z=+366.1 (M+H)+.
出典と根拠
- ORDレコード
- ord-95d2f4282cff4070b79243a00edcd6b6
- 出典データセット
- uspto-grants-2014_12
- 特許番号
- US08901313B2
関連ノート
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