N,N,4-Trimethyl-5-nitropyridin-2-amine → N2,N2,4-trimethylpyridine-2,5-diamine

HRID 1398859ノート

反応式

HRID 1398859 の反応式
[CH3:1][N:2]([CH3:13])[C:3]1[CH:8]=[C:7]([CH3:9])[C:6]([N+:10]([O-])=O)=[CH:5][N:4]=1>C(O)C.[Pd]>[CH3:13][N:2]([CH3:1])[C:3]1[CH:8]=[C:7]([CH3:9])[C:6]([NH2:10])=[CH:5][N:4]=1

参加物

4

反応物 1

HCID 21857174N,N,4-Trimethyl-5-nitropyridin-2-amine

生成物 1

HCID 22136281N2,N2,4-trimethylpyridine-2,5-diamine収率 119.9%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

To a solution of N,N,4-trimethyl-5-nitropyridin-2-amine (15.7 g, 86.6 mmol) in ethanol (200 ml) was added 10% palladium on carbon (50% wet, 1.57 g), and the mixture was purged with hydrogen and stirred under balloon pressure hydrogen at room temperature for 2 days. The catalyst was removed by filtration, and the filtrate was concentrated in vacuo to give the title compound as a brown solid (15.7 g), which was used next reaction without purification.

後処理

  1. customthe mixture was purged with hydrogen
  2. customThe catalyst was removed by filtration
  3. concentrationthe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-5a655849ed2d497aa32f9b8103bee117
出典データセット
uspto-grants-2014_12
特許番号
US08901141B2

反応ノート

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