3-Amino-1-propanol → HCID 86632904、化合物

HRID 1398897ノート

反応式

HRID 1398897 の反応式
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][C:5]([F:11])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13].[NH2:15][CH2:16][CH2:17][CH2:18][OH:19]>O1CCCC1.C(OCC)(=O)C>[F:11][C:5]1[CH:6]=[C:7]([N+:8]([O-:10])=[O:9])[C:2]([NH:15][CH2:16][CH2:17][CH2:18][OH:19])=[C:3]([N+:12]([O-:14])=[O:13])[CH:4]=1

参加物

5

反応物 2

HCID 90863-Amino-1-propanolHCID 123611032-Chloro-5-fluoro-1,3-dinitrobenzene

生成物 1

HCID 86632904HCID 86632904、化合物収率 94%

試薬・触媒・溶媒 2

HCID 8028Tetrahydrofuran溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To a stirred solution of 2-chloro-5-fluoro-1,3-dinitrobenzene (3.24 g, 14.7 mmol) in tetrahydrofuran (50 mL) was added 3-amino-1-propanol (2.80 mL, 36.8 mmol) at 0° C. After being stirred for 3 h at room temperature, the mixture was diluted with ethyl acetate, washed with aqueous sodium hydrogen carbonate and brine, dried over sodium sulfate, filtrated, and concentrated in vacuo to give the title compound as a yellow solid (3.59 g, 13.8 mmol, 94%).

後処理

  1. washwashed with aqueous sodium hydrogen carbonate and brine
  2. dry with materialdried over sodium sulfate
  3. filtrationfiltrated
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-abaa26ff97c047ac9604a202f3af3dc2
出典データセット
uspto-grants-2014_12
特許番号
US08901141B2

反応ノート

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