Sodium Hydroxide → 2-(4-Methyl-2,6-dip-tolylpyrimidin-5-yl)pentanoic acid

HRID 1399581ノート

反応式

HRID 1399581 の反応式
[CH3:1][C:2]1[C:7]([CH:8]([CH2:13][CH2:14][CH3:15])[C:9]([O:11]C)=[O:10])=[C:6]([C:16]2[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=2)[N:5]=[C:4]([C:23]2[CH:28]=[CH:27][C:26]([CH3:29])=[CH:25][CH:24]=2)[N:3]=1.[OH-].[Na+]>CO>[CH3:1][C:2]1[C:7]([CH:8]([CH2:13][CH2:14][CH3:15])[C:9]([OH:11])=[O:10])=[C:6]([C:16]2[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=2)[N:5]=[C:4]([C:23]2[CH:24]=[CH:25][C:26]([CH3:29])=[CH:27][CH:28]=2)[N:3]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 66955816Methyl 2-(4-methyl-2,6-dip-tolylpyrimidin-5-yl)pentanoate

生成物 1

HCID 669559252-(4-Methyl-2,6-dip-tolylpyrimidin-5-yl)pentanoic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
100 °C

実験手順

To a solution of methyl 2-(4-methyl-2,6-dip-tolylpyrimidin-5-yl)pentanoate (86 mg; 0.221 mmol) in methanol (2.214 ml) was added a 10 N sodium hydroxide solution (221 μl; 2.21 mmol) and the mixture was heated at 100° C. overnight. The volatiles were removed under reduced pressure and the mixture was acidified by adding 6N hydrochloric acid. The suspension was extracted twice with ethyl acetate. The combined organic layers were washed with brine, dried over magnesium sulphate and concentrated under reduced pressure.

後処理

  1. customThe volatiles were removed under reduced pressure
  2. additionby adding 6N hydrochloric acid
  3. extractionThe suspension was extracted twice with ethyl acetate
  4. washThe combined organic layers were washed with brine
  5. dry with materialdried over magnesium sulphate
  6. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-f6131ff8e4cf4dc79d3051a42ce566a2
出典データセット
uspto-grants-2014_12
特許番号
US08906906B2

反応ノート

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