Sodium Hydroxide → 2-[4-Methyl-6-(1-methylindol-5-yl)-2-phenyl-pyrimidin-5-yl]pentanoic acid

HRID 1399641ノート

反応式

HRID 1399641 の反応式
[CH3:1][C:2]1[C:7]([CH:8]([CH2:13][CH2:14][CH3:15])[C:9]([O:11]C)=[O:10])=[C:6]([C:16]2[CH:17]=[C:18]3[C:22](=[CH:23][CH:24]=2)[N:21]([CH3:25])[CH:20]=[CH:19]3)[N:5]=[C:4]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[N:3]=1.[OH-].[Na+]>CO>[CH3:1][C:2]1[C:7]([CH:8]([CH2:13][CH2:14][CH3:15])[C:9]([OH:11])=[O:10])=[C:6]([C:16]2[CH:17]=[C:18]3[C:22](=[CH:23][CH:24]=2)[N:21]([CH3:25])[CH:20]=[CH:19]3)[N:5]=[C:4]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[N:3]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 66955926Methyl 2-(4-methyl-6-(1-methyl-1H-indol-5-yl)-2-phenylpyrimidin-5-yl)pentanoate

生成物 1

HCID 669555302-[4-Methyl-6-(1-methylindol-5-yl)-2-phenyl-pyrimidin-5-yl]pentanoic acid収率 77.2%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

This compound was prepared according to general procedure D from methyl 2-(4-methyl-6-(1-methyl-1H-indol-5-yl)-2-phenylpyrimidin-5-yl)pentanoate (0.106 g; 0.256 mmol), sodium hydroxide 10N (0.256 mL; 2.56 mmol) in methanol (2.5 mL) to afford 0.079 g (76%) of the title compound as a white solid.

後処理

  1. customThis compound was prepared

出典と根拠

ORDレコード
ord-08358328ee7c47e795804e614b1d52ae
出典データセット
uspto-grants-2014_12
特許番号
US08906906B2

反応ノート

読み込み中…