Sodium Hydroxide → 2-[4-Methyl-2-(1-piperidyl)-6-(2,4,5-trifluorophenyl)pyrimidin-5-yl]pentanoic acid

HRID 1399712

反応式

HRID 1399712 の反応式
[CH3:1][C:2]1[C:7]([CH:8]([CH2:13][CH2:14][CH3:15])[C:9]([O:11]C)=[O:10])=[C:6]([C:16]2[CH:21]=[C:20]([F:22])[C:19]([F:23])=[CH:18][C:17]=2[F:24])[N:5]=[C:4]([N:25]2[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]2)[N:3]=1.[OH-].[Na+]>CO>[CH3:1][C:2]1[C:7]([CH:8]([CH2:13][CH2:14][CH3:15])[C:9]([OH:11])=[O:10])=[C:6]([C:16]2[CH:21]=[C:20]([F:22])[C:19]([F:23])=[CH:18][C:17]=2[F:24])[N:5]=[C:4]([N:25]2[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]2)[N:3]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 66955535Methyl 2-(4-methyl-2-(piperidin-1-yl)-6-(2,4,5-trifluorophenyl)pyrimidin-5-yl)pentanoate

生成物 1

HCID 509957342-[4-Methyl-2-(1-piperidyl)-6-(2,4,5-trifluorophenyl)pyrimidin-5-yl]pentanoic acid収率 31%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

This compound was prepared according to general method D from methyl 2-(4-methyl-2-(piperidin-1-yl)-6-(2,4,5-trifluorophenyl)pyrimidin-5-yl)pentanoate (0.080 g; 0.190 mmol), sodium hydroxide 10N (0.200 mL; 2.00 mmol) in methanol (2 mL) at 60° C. for 18 h. Purification by flash-chromatography on silica gel using a gradient of methanol (1-10%) in dichloromethane and then by preperative HPLC (HPLC method 1) furnished 0.0024 g (31%) of the title compound as a white solid.

後処理

  1. customThis compound was prepared
  2. customPurification by flash-chromatography on silica gel using a gradient of methanol (1-10%) in dichloromethane

出典と根拠

ORDレコード
ord-6fb671f07ffa46ae89788f4d5d79940a
出典データセット
uspto-grants-2014_12
特許番号
US08906906B2

関連ノート

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