Methanol → 4-((5-bromo-1H-pyrazol-1-yl)methyl)benzoic acid
反応式
[Br:1][C:2]1[N:6]([CH2:7][C:8]2[CH:17]=[CH:16][C:11]([C:12]([O:14]C)=[O:13])=[CH:10][CH:9]=2)[N:5]=[CH:4][CH:3]=1.[OH-].[Na+].CO>O>[Br:1][C:2]1[N:6]([CH2:7][C:8]2[CH:17]=[CH:16][C:11]([C:12]([OH:14])=[O:13])=[CH:10][CH:9]=2)[N:5]=[CH:4][CH:3]=1参加物
5
実験手順
Methyl 4-((5-bromo-1H-pyrazol-1-yl)methyl)benzoate (264 mg, 0.95 mmol), NaOH (200 mg, 5 mmol) were placed in a 100-mL flask with covered with MeOH and H2O (1:1) and stirred for 4 h at room temperature. The solution was then evaporated, taken up in water and acidified with 2M HCl with the resulting the solid filtered off yielding the desired product as a white solid (200 mg, 90%). LCMS (m/z): 281.1 [M+H]+
後処理
- customThe solution was then evaporated
- filtrationfiltered off
出典と根拠
- ORDレコード
- ord-6d69a423580d414abfd7f6a1d18e9398
- 出典データセット
- uspto-grants-2014_12
- 特許番号
- US08906900B2
反応ノート
読み込み中…