Sodium Hydroxide → 2-(2-Phenyloxazol-4-yl)nicotinic acid

HRID 1400240ノート

反応式

HRID 1400240 の反応式
[OH-].[Na+].[C:3]1([C:9]2[O:10][CH:11]=[C:12]([C:14]3[N:24]=[CH:23][CH:22]=[CH:21][C:15]=3[C:16]([O:18]CC)=[O:17])[N:13]=2)[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>CCO>[C:3]1([C:9]2[O:10][CH:11]=[C:12]([C:14]3[N:24]=[CH:23][CH:22]=[CH:21][C:15]=3[C:16]([OH:18])=[O:17])[N:13]=2)[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 67540589Ethyl 2-(2-phenyloxazol-4-yl)nicotinate

生成物 1

HCID 675401952-(2-Phenyloxazol-4-yl)nicotinic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

An aqueous solution of NaOH (0.27 mL, 2M in water, 0.54 mmol) was added to a solution of ethyl 2-(2-phenyloxazol-4-yl)nicotinate (80 mg, 0.27 mmol) in EtOH (2.7 mL). After stirring overnight at room temperature the solvent was removed in vacuo, the residue was dissolved in water and HCl (2M in water) was added until pH ˜1 was obtained. The solvent was removed in vacuo and the crude product obtained was used without further purification; ESI-MS [M+H+]=267.1.

後処理

  1. customwas removed in vacuo
  2. dissolutionthe residue was dissolved in water
  3. additionHCl (2M in water) was added until pH ˜1
  4. customwas obtained
  5. customThe solvent was removed in vacuo

出典と根拠

ORDレコード
ord-61af3a1a91dc4ddaba4b262e17fdf8cc
出典データセット
uspto-grants-2014_12
特許番号
US08906941B2

反応ノート

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