3-Nitro[1,1'-biphenyl]-2-amine → 102877-92-9

HRID 1401118ノート

反応式

HRID 1401118 の反応式
[NH2:1][C:2]1[C:7]([N+:8]([O-])=O)=[CH:6][CH:5]=[CH:4][C:3]=1[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>[Fe].CC(O)=O>[NH2:1][C:2]1[C:7]([NH2:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

参加物

4

反応物 1

HCID 131499333-Nitro[1,1'-biphenyl]-2-amine

生成物 1

HCID 18968019102877-92-9

試薬・触媒・溶媒 2

HCID 23925Iron触媒HCID 176Acetic Acid溶媒

反応条件

温度
60 °C

実験手順

2-Amino-3-nitrobiphenyl d (0.613 g, 2.86 mmol) was purged under nitrogen for 30 minutes then HOAc (5 mL) was added followed by iron powder (0.4895 g, 8.76 mmol). The sample was heated at 60° C. for 30 minutes then HOAc (5 mL) was added. The sample was stirred at 60° C. for 1 hour then poured into ice. The sample was extracted with EtOAc (3×100 mL). The EtOAc extracts were washed with saturated NaHCO3 (3×100 mL. The EtOAc layer was dried over MgSO4, filtered, and concentrated to give 2,3-diaminobiphenyl e (0.439 g, 2.38 mmol, 83%).

後処理

  1. customwas purged under nitrogen for 30 minutes
  2. additionHOAc (5 mL) was added
  3. additionthen poured into ice
  4. extractionThe sample was extracted with EtOAc (3×100 mL)
  5. washThe EtOAc extracts were washed with saturated NaHCO3 (3×100 mL
  6. dry with materialThe EtOAc layer was dried over MgSO4
  7. filtrationfiltered
  8. concentrationconcentrated

出典と根拠

ORDレコード
ord-8eb068e5d8fc4e4081fa55a501164e4d
出典データセット
uspto-grants-2014_12
特許番号
US08907092B2

反応ノート

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