Trifluoroacetic acid → 5-Bromo-6-methylpicolinamide

HRID 1401212ノート

反応式

HRID 1401212 の反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:9]#[N:10])=[N:6][C:7]=1[CH3:8].C(O)(C(F)(F)F)=[O:12]>S(=O)(=O)(O)O>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:9]([NH2:10])=[O:12])=[N:6][C:7]=1[CH3:8]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 498187795-Bromo-6-methylpyridine-2-carbonitrile

生成物 1

HCID 666077245-Bromo-6-methylpicolinamide収率 54%

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

反応条件

温度
40 °C

実験手順

A solution of 5-bromo-6-methylpicolinonitrile (1.8 g, 9.14 mmol) in a mixture of TFA and sulfuric acid (30 mL, 4:1, V/V) was stirred at 40° C. for 16 h. The reaction mixture was poured into ice water. The resulting solid was filtered off and washed with water and dried to give the desired product as a white solid (1.0 g, 4.65 mmol, 54% yield). MS (ESI) m/z 217.1 [M+2]+.

後処理

  1. filtrationThe resulting solid was filtered off
  2. washwashed with water
  3. customdried

出典と根拠

ORDレコード
ord-d2ade860c462460a948a4b5639c0c91b
出典データセット
uspto-grants-2014_12
特許番号
US08907087B2

反応ノート

読み込み中…