Aluminium lithium hydride → HCID 67323188、化合物

HRID 1401786ノート

反応式

HRID 1401786 の反応式
[H-].[Al+3].[Li+].[H-].[H-].[H-].[OH:7][C@H:8]1[CH2:12][CH2:11][NH:10][C@@H:9]1[C:13]([N:15]1[CH2:20][CH2:19][CH:18]([C:21]2[S:22][CH:23]=[C:24]([C:26]3[CH:35]=[CH:34][C:33]4[C:32]([CH3:37])([CH3:36])[CH2:31][CH2:30][C:29]([CH3:39])([CH3:38])[C:28]=4[CH:27]=3)[N:25]=2)[CH2:17][CH2:16]1)=O>C1COCC1>[CH3:36][C:32]1([CH3:37])[CH2:31][CH2:30][C:29]([CH3:38])([CH3:39])[C:28]2[CH:27]=[C:26]([C:24]3[N:25]=[C:21]([CH:18]4[CH2:17][CH2:16][N:15]([CH2:13][C@@H:9]5[C@@H:8]([OH:7])[CH2:12][CH2:11][NH:10]5)[CH2:20][CH2:19]4)[S:22][CH:23]=3)[CH:35]=[CH:34][C:33]1=2

参加物

4

反応物 2

HCID 21226445Aluminium lithium hydrideHCID 67323751HCID 67323751、化合物

生成物 1

HCID 67323188HCID 67323188、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

The preparation was carried out as already described using a 2N lithium aluminium hydride solution in THF starting from 30 mg (0.06 mmol) of ((2S,3S)-3-hydroxypyrrolidin-2-yl)-{4-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperidin-1-yl}methanone. The product was purified by means of preparative HPLC and is in the form of the hydrochloride.

後処理

  1. customThe product was purified by means of preparative HPLC

出典と根拠

ORDレコード
ord-3beb4fc1e3434a808a72517ef4ec76b1
出典データセット
uspto-grants-2014_12
特許番号
US08907098B2

反応ノート

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