Acetic Anhydride → N-Acetyl-D-serine
反応式
[C:1](OC(=O)C)(=[O:3])[CH3:2].[NH2:8][C@H:9]([CH2:13][OH:14])[C:10]([OH:12])=[O:11]>C(O)(=O)C>[C:1]([NH:8][C@H:9]([CH2:13][OH:14])[C:10]([OH:12])=[O:11])(=[O:3])[CH3:2]参加物
4
反応条件
- 温度
- 32.5 °C
実験手順
Acetic anhydride (23.4 ml) was added to the suspension of (R)-2-amino-3-hydroxypropanoic acid compound of formula-3 (20 grams) in acetic acid (300 ml) and stirred for 24 hours at 30-35° C. After completion of the reaction, acetic acid was removed by distillation followed by co-distillation with tetrahydrofuran. Isopropyl alcohol (60 ml) and methyltertiarybutylether (120 ml) was added to the obtained residue and stirred for 30 minutes. The obtained solid was filtered off and then solvent from the filtrate was distilled off completely under reduced pressure to get the title compound.
後処理
- customwas removed by distillation
- additionIsopropyl alcohol (60 ml) and methyltertiarybutylether (120 ml) was added to the obtained residue
- stirringstirred for 30 minutes
- filtrationThe obtained solid was filtered off
- distillationsolvent from the filtrate was distilled off completely under reduced pressure
出典と根拠
- ORDレコード
- ord-1527d0c2ec9c4fb6a7de60d6d9135503
- 出典データセット
- uspto-grants-2014_12
- 特許番号
- US08907132B2
反応ノート
読み込み中…