Hydrochloric Acid → HCID 25129245、化合物

HRID 1402684ノート

反応式

HRID 1402684 の反応式
[OH:1][C@H:2]([C:21]1[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][CH:22]=1)[C@H:3]([NH:10][C:11](=[O:20])OCC1C=CC=CC=1)[CH2:4][N:5]1[CH2:9][CH2:8][CH2:7][CH2:6]1.Cl.[CH3:30][CH2:31][OH:32]>[Pd]>[OH:1][C@H:2]([C:21]1[CH:22]=[CH:23][C:24]([O:27][CH3:28])=[CH:25][CH:26]=1)[C@H:3]([NH:10][C:11](=[O:20])[CH2:30][CH2:31][O:32][C:24]1[CH:25]=[CH:26][C:21]([CH3:2])=[CH:22][CH:23]=1)[CH2:4][N:5]1[CH2:6][CH2:7][CH2:8][CH2:9]1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 59531008HCID 59531008、化合物

生成物 1

HCID 25129245HCID 25129245、化合物収率 85%

試薬・触媒・溶媒 1

HCID 23938Palladium触媒

実験手順

A mixture of benzyl(1R,2R)-1-hydroxy-1-(4-methoxyphenyl)-3-(pyrrolidin-1-yl)propan-2-ylcarbamate (0.10 g, 0.26 mmol) and Pd/C (5%, 21 mg) in EtOH (1 mL)/HCl (1 M, 50 μL) was degassed and hydrogen gas was added. The mixture was hydrogenated at atmospheric pressure for two hours. The mixture was filtered over celite and the solvent was removed to dryness. The product was obtained as a colorless oil (63.5 mg, 85% yield).

後処理

  1. customwas degassed
  2. additionhydrogen gas was added
  3. filtrationThe mixture was filtered over celite
  4. customthe solvent was removed to dryness

出典と根拠

ORDレコード
ord-80a6d3c15e304df08e207dfa9f0bc1f2
出典データセット
uspto-grants-2014_12
特許番号
US08912177B2

反応ノート

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