Ammonia → 7-Bromoquinolin-5-ol

HRID 1402691ノート

反応式

HRID 1402691 の反応式
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][CH:8]=[N:9]2)=[C:4]([O:12]C)[CH:3]=1.Br.N>O>[OH:12][C:4]1[CH:3]=[C:2]([Br:1])[CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][CH:8]=[N:9]2

参加物

5

反応物 3

HCID 222AmmoniaHCID 260Hydrogen BromideHCID 712378127-Bromo-5-methoxyquinoline

生成物 1

HCID 1362166197-Bromoquinolin-5-ol

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

1.5 g (0.0064 mol) of 7-bromo-5-methoxy-quinoline were refluxed with 48% HBr (30 ml) for 20 h. After cooling to room temperature reaction mixture was poured into 100 ml of water and basified with saturated ammonia solution. Product was filtered off, washed with water and dried at 50° C. in vacuo. Yield of 7-bromo-5-hydroxy-quinoline was 600 mg (41%).

後処理

  1. customreaction mixture
  2. filtrationProduct was filtered off
  3. washwashed with water
  4. customdried at 50° C. in vacuo

出典と根拠

ORDレコード
ord-28981c1d283947eaa84e8e876f62703f
出典データセット
uspto-grants-2014_12
特許番号
US08912173B2

反応ノート

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