Methyl iodide → 7-Bromo-3-methyl-3,4-dihydroquinazolin-4-one

HRID 1402700ノート

反応式

HRID 1402700 の反応式
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:12])[NH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[CH3:13]I>CN(C=O)C>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:12])[N:7]([CH3:13])[CH:8]=[N:9]2)=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 6328Methyl iodide2 回HCID 1355556127-Bromo-3,4-dihydroquinazolin-4-one

生成物 1

HCID 585745147-Bromo-3-methyl-3,4-dihydroquinazolin-4-one

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
25 °C

実験手順

400 mg 7-Bromoquinazolin-4(3H)-one was dissolved in DMF and 720 mg of CsCO3 and 130 μL of methyliodide were added and the mixture stirred for 3 h at 25° C. Additional 50 μL methyliodide were added and stirred overnight at 25° C. The mixture was filtered off and the mother liquor diluted with DCM and extracted with water. The solvent was removed to yield 490 mg of 7-bromo-3-methylquinazolin-4(3H)-one as solid.

後処理

  1. stirringstirred overnight at 25° C
  2. filtrationThe mixture was filtered off
  3. additionthe mother liquor diluted with DCM
  4. extractionextracted with water
  5. customThe solvent was removed

出典と根拠

ORDレコード
ord-639b2e47d74645d59079c67fd81c8d20
出典データセット
uspto-grants-2014_12
特許番号
US08912173B2

反応ノート

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