Sodium Hydroxide → (6-Methylpyridin-3-yl)acetic acid
反応式
[CH3:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][C:9]([O:11]C)=[O:10])=[CH:4][CH:3]=1.[OH-].[Na+]>CO>[CH3:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[CH:4][CH:3]=1参加物
4
反応条件
- 温度
- 65 °C
実験手順
To a stirred solution of methyl (6-methylpyridin-3-yl)acetate (60 mg, 0.36 mmol) in methanol (5 ml) was added NaOH (1.0 ml of a 2M aqueous solution, 2.0 mmol) and the resulting solution was heated at 65° C. for 2 hours. The solvent was then removed at reduced pressure and the resulting residue was dissolved in methanolic HCl (5 ml) and then reconcentrated to yield the title product (54 mg, quant. yield) that was used without further purification.
後処理
- customThe solvent was then removed at reduced pressure
- dissolutionthe resulting residue was dissolved in methanolic HCl (5 ml)
出典と根拠
- ORDレコード
- ord-c3ba509f4e4840ceab22ea9d201ac51e
- 出典データセット
- uspto-grants-2014_12
- 特許番号
- US08912176B2
反応ノート
読み込み中…