化工社化工社 化学情報印刷レポート · 研究参考用
Ethyl chloroacetate → Glycine, N-(4-chlorophenyl)-, ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl chloroacetate | HCID 7751 | — |
| 反応物 | 4-Chloroaniline | HCID 7812 | — |
| 反応物 | Sodium Acetate Trihydrate | HCID 23665404 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | Glycine, N-(4-chlorophenyl)-, ethyl ester | HCID 302644 | 55.9% |
反応手順
Sodium acetate trihydrate (6 g) was added to a solution of commercial ethyl chloroacetate (6.2 g) and commercial 4-chloroaniline (6.4 g) in ethanol (5 ml). The mixture was heated to reflux for 5 h. After cooling in an ice bath the product precipitates. The solid was collected by suction filtration and washed with water. The still wet product was recrystallised from ethanol to give ethyl N-(4-chlorophenyl)glycinate (5.99 g) as greyish crystals.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08912186B2 |
| 出典データセット | uspto-grants-2014_12 |
| ORD ID | ord-f4611cbfb3fb4deea75c22e6bec2aa55 |
| 出典メモ | uspto-grants-2014_12 |