Sodium Hydroxide → 2-((4-Chlorophenyl)amino)acetic acid

HRID 1402841

反応式

HRID 1402841 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][CH2:9][C:10]([O:12]CC)=[O:11])=[CH:4][CH:3]=1.[OH-].[Na+]>C(O)C.O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][CH2:9][C:10]([OH:12])=[O:11])=[CH:6][CH:7]=1

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 302644Glycine, N-(4-chlorophenyl)-, ethyl ester

生成物 1

HCID 2307172-((4-Chlorophenyl)amino)acetic acid

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

To the suspension of ethyl N-(4-chlorophenyl)-glycinate (10.4 g) in ethanol (4 ml) the solution of NaOH (4 g) in water (40 ml) was added. Upon heating a clear solution is formed, which is refuxed for 0.5 h. The solution is decolorized with activated carbon and filtered while hot. The filtrate is cooled in an ice bath and conc. HCl (5 ml) is added dropwise with stirring (pH 1-2). The precipitate formed is collected by suction filtration and washed with water. After drying in vacuo N-(4-chlorophenyl)-glycine (6.51 g) is obtained as colourless crystals.

後処理

  1. additionwas added
  2. temperatureUpon heating a clear solution
  3. customis formed
  4. filtrationfiltered while hot
  5. temperatureThe filtrate is cooled in an ice bath
  6. additionconc. HCl (5 ml) is added dropwise
  7. customThe precipitate formed
  8. filtrationis collected by suction filtration
  9. washwashed with water
  10. dry with materialAfter drying in vacuo N-(4-chlorophenyl)-glycine (6.51 g)
  11. customis obtained as colourless crystals

出典と根拠

ORDレコード
ord-eb77f9c75a8d4d51aed09c4e87f57389
出典データセット
uspto-grants-2014_12
特許番号
US08912186B2

関連ノート

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