Bromine → 5-bromo-7H-pyrrolo[2,3-d]pyrimidine
反応式
[N:1]1[C:6]2[NH:7][CH:8]=[CH:9][C:5]=2[CH:4]=[N:3][CH:2]=1.[Br:10]Br>C(Cl)(Cl)Cl.C(Cl)(Cl)(Cl)Cl>[Br:10][C:9]1[C:5]2[CH:4]=[N:3][CH:2]=[N:1][C:6]=2[NH:7][CH:8]=1参加物
5
実験手順
5-Bromo-7H-pyrrolo[2,3-d]pyrimidine (7) is prepared by dissolving 7H-pyrrolo[2,3-d]pyrimidine (6) in chloroform and slowly adding Br2 in carbon tetrachloride at 0° C. After stirring for 1-2 hours, the reaction may be quenched in aqueous hydrochloric acid. Isolation by conventional means (e.g. extraction and silica gel chromatography) provides compound 7.
後処理
- custom5-Bromo-7H-pyrrolo[2,3-d]pyrimidine (7) is prepared
- customthe reaction
- custommay be quenched in aqueous hydrochloric acid
- extractionIsolation by conventional means (e.g. extraction and silica gel chromatography)
出典と根拠
- ORDレコード
- ord-524cbe2d29854b478a60fad5a21d2026
- 出典データセット
- uspto-grants-2014_12
- 特許番号
- US08912204B2
反応ノート
読み込み中…