Hydrogen Bromide → 4-Bromo-2-phenylfuran
反応式
O[CH2:2][C:3]#[C:4][C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)=[O:6].[BrH:13].O>C1(C)C=CC=CC=1>[Br:13][C:3]1[CH:4]=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[O:6][CH:2]=1参加物
5
反応条件
- 温度
- 50 °C
実験手順
To a solution of 4-hydroxy-1-phenylbut-2-yn-1-one (3.2 g, crude) in toluene (60 mL) was added HBr (40%, 15 mL). The resulting solution was stirred for 40 min at 50° C. and then the reaction mixture was poured into water (300 mL), extracted with Et2O (4×100 mL), dried over anhydrous sodium sulfate and then concentrated in vacuo to give a residue, which was purified by silica gel column chromatography (petroleum ether) to afford 4-bromo-2-phenylfuran as a yellow solid (1.3 g, 50%).
後処理
- extractionextracted with Et2O (4×100 mL)
- dry with materialdried over anhydrous sodium sulfate
- concentrationconcentrated in vacuo
- customto give a residue, which
- customwas purified by silica gel column chromatography (petroleum ether)
出典と根拠
- ORDレコード
- ord-3b876a5ebd294dedb25b0d55e8182d8e
- 出典データセット
- uspto-grants-2014_12
- 特許番号
- US08912188B2
反応ノート
読み込み中…