Water → HCID 178461408、化合物

HRID 1403529ノート

反応式

HRID 1403529 の反応式
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[C:19]([N:20]4[CH2:24][CH2:23][CH2:22][C@@H:21]4[CH3:25])=[N:18][C:17]4[C:12](=[CH:13][CH:14]=[C:15]([C:26]([O:28]C)=[O:27])[CH:16]=4)[N:11]=3)=[CH:9][C:4]=2[N:3]=[N:2]1.[OH-].[Na+].O>CO>[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[C:19]([N:20]4[CH2:24][CH2:23][CH2:22][C@@H:21]4[CH3:25])=[N:18][C:17]4[C:12](=[CH:13][CH:14]=[C:15]([C:26]([OH:28])=[O:27])[CH:16]=4)[N:11]=3)=[CH:9][C:4]=2[N:3]=[N:2]1

参加物

5

反応物 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 178497313HCID 178497313、化合物

生成物 1

HCID 178461408HCID 178461408、化合物収率 73.1%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of (S)-methyl 2-(1H-benzo[d][1,2,3]triazol-5-yl)-3-(2-methylpyrrolidin-1-yl)quinoxaline-6-carboxylate (130 mg, 0.33 mmol) in methanol (30 mL) was added sodium hydroxide (40.2 mg, 1.00 mmol) and water (1 mL) with stirring for overnight at room temperature. The resulting mixture was concentrated under vacuum and dissolved in water (25 mL), and adjusted to pH 4 with HCl (3N) to give the precipitate, which was collected by filtration to afford (S)-2-(1H-benzo[d][1,2,3]triazol-5-yl)-3-(2-methylpyrrolidin-1-yl)quinoxaline-6-carboxylic acid as a yellow solid (90.3 mg, 72%).

後処理

  1. concentrationThe resulting mixture was concentrated under vacuum
  2. dissolutiondissolved in water (25 mL)
  3. customto give the precipitate, which
  4. filtrationwas collected by filtration

出典と根拠

ORDレコード
ord-a110521f8b8d436a9154b3adfaefb9b8
出典データセット
uspto-grants-2014_12
特許番号
US08912188B2

反応ノート

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