Methyl triflate → 3-methyl-1-(N-methyl-N-phenylsulfamoyl)-1H-imidazol-3-ium trifluoromethanesulfonate
反応式
[CH3:1][N:2]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[S:3]([N:6]1[CH:10]=[CH:9][N:8]=[CH:7]1)(=[O:5])=[O:4].[O:17](C)[S:18]([C:21]([F:24])([F:23])[F:22])(=[O:20])=[O:19]>C(Cl)Cl>[F:22][C:21]([F:24])([F:23])[S:18]([O-:20])(=[O:19])=[O:17].[CH3:21][N+:8]1[CH:9]=[CH:10][N:6]([S:3](=[O:4])(=[O:5])[N:2]([CH3:1])[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:7]=1参加物
4
反応条件
- 温度
- 0 °C
実験手順
To a solution of N-methyl-N-phenyl-1H-imidazole-1-sulfonamide (700 mg, 2.95 mmol) in dry DCM (5 mL) was added methyl triflate (725 mg, 4.4 mmol) under nitrogen at 0° C. The mixture was stirred at 0° C. for 3 h and at a temperature below 10° C. for 12 h. After the solvent was removed, the residue was used in next step without further purification. LCMS (ESI): m/z 237.9 [M+H+].