Phenol → Phenyl 1H-imidazole-1-sulfonate

HRID 1403722ノート

反応式

HRID 1403722 の反応式
[C:1]1([OH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[S:8](N1C=CN=C1)([N:11]1[CH:15]=[CH:14][N:13]=[CH:12]1)(=[O:10])=[O:9].C([O-])([O-])=O.[Cs+].[Cs+]>C1COCC1>[N:11]1([S:8]([O:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)(=[O:10])=[O:9])[CH:15]=[CH:14][N:13]=[CH:12]1

参加物

5

反応物 3

HCID 996PhenolHCID 10796Cesium carbonateHCID 816091,1'-sulphonylbis-1H-imidazole

生成物 1

HCID 90409877Phenyl 1H-imidazole-1-sulfonate収率 60.2%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of phenol (400 mg, 4.3 mmol) in THF (25 mL) was added 1,1′-sulfonyldiimidazole (1.0 g, 5.1 mmol) and Cs2CO3 (2.8 g, 8.5 mmol). The mixture was stirred at ambient temperature for 16 h. The solvent was removed and the residue was purified by silica gel chromatography to yield the title compound (580 mg, 60%).

後処理

  1. customThe solvent was removed
  2. customthe residue was purified by silica gel chromatography

出典と根拠

ORDレコード
ord-3d58a4fabebf41b3a136f564eca7e95a
出典データセット
uspto-grants-2014_12
特許番号
US08912219B2

反応ノート

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