2,4-Dimethoxybenzylamine → Methyl 2-(3-(2,4-dimethoxybenzylamino)cyclobutyl)acetate

HRID 1404375ノート

反応式

HRID 1404375 の反応式
O=[C:2]1[CH2:5][CH:4]([CH2:6][C:7]([O:9][CH3:10])=[O:8])[CH2:3]1.[CH3:11][O:12][C:13]1[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][C:14]=1[CH2:21][NH2:22]>[Pd].CO>[CH3:11][O:12][C:13]1[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][C:14]=1[CH2:21][NH:22][CH:2]1[CH2:5][CH:4]([CH2:6][C:7]([O:9][CH3:10])=[O:8])[CH2:3]1

参加物

5

反応物 2

HCID 5972502,4-DimethoxybenzylamineHCID 57686718Methyl 2-(3-oxocyclobutyl)acetate

生成物 1

HCID 86722980Methyl 2-(3-(2,4-dimethoxybenzylamino)cyclobutyl)acetate収率 96.7%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To methyl 2-(3-oxocyclobutyl)acetate (426 mg) and (2,4-dimethoxyphenyl)methanamine (501 mg) in a flask was added MeOH (20 mL) and Pd/C (10%, 100 mg). The reaction mixture was stirred under hydrogen atmosphere for overnight. Catalyst was removed by filtration through the Celite pad. Removal of the solvent afforded the crude product (850 mg) which was used directly to the next step without further purification.

後処理

  1. customCatalyst was removed by filtration through the Celite pad
  2. customRemoval of the solvent

出典と根拠

ORDレコード
ord-5bb4f1d4744f48f28d4f81e3eb256e56
出典データセット
uspto-grants-2014_12
特許番号
US08912169B2

反応ノート

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