Ethanolamine → 2-(4-(3-Azidopropylamino)-6-chloro-1,3,5-triazin-2-ylamino)ethanol

HRID 1404416ノート

反応式

HRID 1404416 の反応式
[CH2:1]([CH2:3][NH2:4])[OH:2].[N:5]([CH2:8][CH2:9][CH2:10][NH:11][C:12]1[N:17]=[C:16](Cl)[N:15]=[C:14]([Cl:19])[N:13]=1)=[N+:6]=[N-:7]>CC(C)=O>[N:5]([CH2:8][CH2:9][CH2:10][NH:11][C:12]1[N:13]=[C:14]([Cl:19])[N:15]=[C:16]([NH:4][CH2:3][CH2:1][OH:2])[N:17]=1)=[N+:6]=[N-:7]

参加物

4

反応物 2

HCID 700EthanolamineHCID 86672179N-(3-azidopropyl)-4,6-dichloro-1,3,5-triazin-2-amine

生成物 1

HCID 866721782-(4-(3-Azidopropylamino)-6-chloro-1,3,5-triazin-2-ylamino)ethanol収率 85%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒2 回

実験手順

Ethanolamine (2.47 g, 40.4 mmol) in acetone (20 mL) was added to a solution of 1 (2.0 g, 8.1 mmol) in acetone (30 mL). The reaction was stirred at room temperature for 24 hours. The acetone was removed by rotary evaporation and the residue was suspended in CH2Cl2. The mixture was filtered off. The solid collected was washed with CH2Cl2 with H2O and dried under reduced pressure to afford 2 as a white solid (1.86 g, 85%). The product is sufficiently pure for further reactions. ESI-MS m/z 273.1 (M+H+) calculated for C8H14ClN8O 273.1.

後処理

  1. customThe acetone was removed by rotary evaporation
  2. filtrationThe mixture was filtered off
  3. customThe solid collected
  4. washwas washed with CH2Cl2 with H2O
  5. customdried under reduced pressure

出典と根拠

ORDレコード
ord-e46ae5180b6c47dca94b788e95b4ccbc
出典データセット
uspto-grants-2014_12
特許番号
US08912323B2

反応ノート

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