Benzoyl chloride → Benzophenone

反応式

Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1OCCC.[Cl-].[Al+3].[Cl-].[Cl-].[C:16](Cl)(=[O:23])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>ClCCl>[C:16]([C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)(=[O:23])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

参加物

反応条件

温度: 0 °C

実験手順

69.7 g (324.2 mmol) of 1-bromo-2-propoxybenzene was added dropwise to a dichloromethane (350 ml) solution containing 51.8 g (388.6 mmol) of aluminum chloride and 45.6 g (324.3 mmol) of benzoyl chloride which was cooled to 0° C. After addition, the resulting solution was stirred for 2 hours. After a reaction, the reaction solution was washed with water, the solvent was removed, and the obtained product was purified by column chromatography to obtain a benzophenone derivative represented by the following formula (40) as 67.3 g (210.7 mmol, yield of 65%) of a yellow solid.