Hydrochloric Acid → HCID 178509540、化合物

HRID 1404907ノート

反応式

HRID 1404907 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1Cl)[C:5]#[N:6].[C:11](=[S:16])(OCC)[S-:12].[K+].Cl>CN(C=O)C.O>[C:5]([C:4]1[CH:7]=[CH:8][C:9]2[S:12][C:11]([SH:16])=[N:1][C:2]=2[CH:3]=1)#[N:6]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 1044643-Amino-4-chlorobenzonitrileHCID 2735045Potassium ethylxanthate

生成物 1

HCID 178509540HCID 178509540、化合物収率 76.1%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

反応条件

温度
115 °C

実験手順

A mixture of 3-amino-4-chloro benzonitrile (13, 0.50 g, 3.28 mmol) and potassium O-ethyl dithiocarbonate (1.05 g, 6.55 mmol) in DMF (15 mL) was heated overnight at 110-120° C. under N2. After cooling, the reaction mixture was diluted with water and acidified with 1N HCl. The precipitate was collected by filtration, washed with water, and dried under vacuum to yield 14 (0.48 g, 76%).

後処理

  1. temperatureAfter cooling
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with water
  4. customdried under vacuum

出典と根拠

ORDレコード
ord-58491280b04643bcbe6067d240e6a43f
出典データセット
uspto-grants-2014_12
特許番号
US08916550B2

反応ノート

読み込み中…