Hydrochloric Acid → 2-(Benzo[d]thiazol-2-yloxy)acetic acid

HRID 1404942ノート

反応式

HRID 1404942 の反応式
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[O:10][CH2:11][C:12]([O:14]CC)=[O:13].[OH-].[Na+].Cl>CO>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[O:10][CH2:11][C:12]([OH:14])=[O:13]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 59467898HCID 59467898、化合物

生成物 1

HCID 2435072-(Benzo[d]thiazol-2-yloxy)acetic acid収率 86%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 60 (1.32 g, 5.6 mmol) in MeOH was added NaOH (3M, 75 mL, 0.22 mol) dropwise. The mixture was stirred at room temperature over night. It was then cooled in an ice-water bath and acidified to pH<2 with HCl (2N). The mixture was then extracted with CHCl3 (3×). The combined organic layers were dried over Na2SO4 and concentrated in vacuum to yield 61 as a white solid (1.0 g, 86%).

後処理

  1. temperatureIt was then cooled in an ice-water bath
  2. extractionThe mixture was then extracted with CHCl3 (3×)
  3. dry with materialThe combined organic layers were dried over Na2SO4
  4. concentrationconcentrated in vacuum

出典と根拠

ORDレコード
ord-506823504202427ba8fc1d607fb1f1c8
出典データセット
uspto-grants-2014_12
特許番号
US08916550B2

反応ノート

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