N-Iodosuccinimide → 5-Iodo-2-methylsulfanyl-6-(3-trifluoromethyl-phenyl)-pyrimidin-4-ylamine

HRID 1405036ノート

反応式

HRID 1405036 の反応式
[CH3:1][S:2][C:3]1[N:8]=[C:7]([NH2:9])[CH:6]=[C:5]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([C:16]([F:19])([F:18])[F:17])[CH:11]=2)[N:4]=1.C1C(=O)N([I:27])C(=O)C1>>[I:27][C:6]1[C:7]([NH2:9])=[N:8][C:3]([S:2][CH3:1])=[N:4][C:5]=1[C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([C:16]([F:19])([F:17])[F:18])[CH:11]=1

参加物

3

反応物 2

HCID 120273N-IodosuccinimideHCID 585132282-Methylsulfanyl-6-(3-trifluoromethylphenyl)-pyrimidin-4-ylamine

生成物 1

HCID 585134235-Iodo-2-methylsulfanyl-6-(3-trifluoromethyl-phenyl)-pyrimidin-4-ylamine

実験手順

The title compound is synthesized according to general procedure GP2 starting from 2.0 g (7.0 mmol) 2-methylsulfanyl-6-(3-trifluoromethyl-phenyl)-pyrimidin-4-ylamine and 1.6 g (7.0 mmol) NIS. Yield after precipitation: 1.9 g (66%).

後処理

  1. customYield
  2. customafter precipitation

出典と根拠

ORDレコード
ord-9f61f229d26842f7bf28adfc27d02f10
出典データセット
uspto-grants-2014_12
特許番号
US08916548B2

反応ノート

読み込み中…