N-Iodosuccinimide → 4-Chloro-6-ethyl-5-iodo-pyrimidin-2-ylamine

HRID 1405039ノート

反応式

HRID 1405039 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([CH2:8][CH3:9])[N:5]=[C:4]([NH2:10])[N:3]=1.C1C(=O)N([I:18])C(=O)C1>>[Cl:1][C:2]1[C:7]([I:18])=[C:6]([CH2:8][CH3:9])[N:5]=[C:4]([NH2:10])[N:3]=1

参加物

3

反応物 2

HCID 120273N-IodosuccinimideHCID 223243042-Amino-4-chloro-6-ethylpyrimidine

生成物 1

HCID 585132964-Chloro-6-ethyl-5-iodo-pyrimidin-2-ylamine

実験手順

The title compound is synthesized according to general procedure GP1 starting from 2.5 g (16 mmol) 4-chloro-6-ethyl-pyrimidin-2-ylamine and 3.7 g (16 mmol) NIS. Yield after precipitation from the reaction mixture: 3.83 g (85%).

後処理

  1. customYield
  2. customafter precipitation from the reaction mixture

出典と根拠

ORDレコード
ord-029a2c9929184d88a85d2d5999157e0b
出典データセット
uspto-grants-2014_12
特許番号
US08916548B2

反応ノート

読み込み中…