2,4-Dichloro-1,3,5-triazine → 4-Chloro-N-{3-[(propan-2-ylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine

HRID 1405200ノート

反応式

HRID 1405200 の反応式
Cl[C:2]1[N:7]=[C:6]([Cl:8])[N:5]=[CH:4][N:3]=1.CCN(C(C)C)C(C)C.[Cl-].[CH3:19][CH:20]([S:22]([CH2:25][C:26]1[CH:27]=[C:28]([CH:30]=[CH:31][CH:32]=1)[NH3+:29])(=[O:24])=[O:23])[CH3:21]>C1COCC1.CC(O)C>[Cl:8][C:6]1[N:5]=[CH:4][N:3]=[C:2]([NH:29][C:28]2[CH:30]=[CH:31][CH:32]=[C:26]([CH2:25][S:22]([CH:20]([CH3:21])[CH3:19])(=[O:24])=[O:23])[CH:27]=2)[N:7]=1

参加物

5

反応物 3

HCID 178102,4-Dichloro-1,3,5-triazineHCID 81531DiisopropylethylamineHCID 867296113-[(Propan-2-ylsulfonyl)methyl]anilinium chloride

生成物 1

HCID 891559554-Chloro-N-{3-[(propan-2-ylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine収率 268%

試薬・触媒・溶媒 1

HCID 22597222Tetrahydrofuran 2-propanol溶媒2 回

実験手順

To a stirred solution of 2,4-dichloro-1,3,5-triazine (150 mg, ABCR GmbH & CO. KG) in THF/i-PrOH (1:1; 1.9 mL) DIPEA (0.52 mL) was added at −40° C. Then a suspension of 3-[(propan-2-ylsulfonyl)methyl]anilinium chloride (250 mg) in THF/i-PrOH (1:1, 0.94 mL) was added at this temperature. Under stirring the temperature of the reaction mixture was slowly raised over 3 hours to 0° C. The reaction mixture was then concentrated in vacuo to give the crude title compound (876 mg) which was used without further purification.

後処理

  1. additionwas added at this temperature
  2. temperaturewas slowly raised over 3 hours to 0° C
  3. concentrationThe reaction mixture was then concentrated in vacuo

出典と根拠

ORDレコード
ord-7869f1e9e48f40f3a59f40b90b39107a
出典データセット
uspto-grants-2014_12
特許番号
US08916557B2

反応ノート

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