Sodium Bicarbonate → 1-(4-Methoxyphenyl)piperazine

HRID 1405455ノート

反応式

HRID 1405455 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]2)=[CH:5][CH:4]=1.C(=O)(O)[O-].[Na+]>ClCCl.FC(F)(F)C(O)=O>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[CH:7][CH:8]=1

参加物

5

反応物 2

HCID 516892Sodium BicarbonateHCID 10935225tert-butyl 4-(4-methoxyphenyl)piperazine-1-carboxylate

生成物 1

HCID 2697221-(4-Methoxyphenyl)piperazine収率 98.9%

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 6422Trifluoroacetic acid溶媒

反応条件

温度
20 °C

実験手順

A solution of t-butyl 4-(4-methoxyphenyl)piperazine-1-carboxylate (1.412 g, 4.84 mmol, 1.00 equiv) in dichloromethane (17 mL) and trifluoroacetic acid (6 mL) was placed in a 50-mL round bottom flask and stirred for 2 h at 20° C. in an oil bath. The pH of the solution was adjusted to 7-8 with saturated aqueous sodium bicarbonate. The resulting mixture was concentrated under vacuum yielding 0.92 g (65%) of 1-(4-methoxyphenyl)piperazine as a yellow solid.

後処理

  1. concentrationThe resulting mixture was concentrated under vacuum

出典と根拠

ORDレコード
ord-1f60fdb2644248a0bb815d5f0b2b446a
出典データセット
uspto-grants-2014_12
特許番号
US08916560B2

反応ノート

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