9-Biphenyl-4-yl-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazine 2,2-dioxide → 9-Biphenyl-4-yl-3,4,6,7,8,9-hexahydropyrido[2,1-c][1,2,4]thiadiazine 2,2-dioxide

HRID 1405662ノート

反応式

HRID 1405662 の反応式
[C:1]1([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:6]=[CH:5][C:4]([C:7]2[C:12]3=[N:13][S:14](=[O:18])(=[O:17])[CH2:15][CH2:16][N:11]3[CH:10]=[CH:9][CH:8]=2)=[CH:3][CH:2]=1>C1COCC1.[C].[Pd]>[C:1]1([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:2]=[CH:3][C:4]([CH:7]2[C:12]3=[N:13][S:14](=[O:17])(=[O:18])[CH2:15][CH2:16][N:11]3[CH2:10][CH2:9][CH2:8]2)=[CH:5][CH:6]=1

参加物

4

反応物 1

HCID 667489979-Biphenyl-4-yl-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazine 2,2-dioxide

生成物 1

HCID 667481379-Biphenyl-4-yl-3,4,6,7,8,9-hexahydropyrido[2,1-c][1,2,4]thiadiazine 2,2-dioxide収率 104.8%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of 10% palladium-carbon (50% wet, 12 mg) and 9-biphenyl-4-yl-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazine 2,2-dioxide (115 mg) in THF (50 mL) was stirred under a hydrogen atmosphere overnight. The reaction mixture was filtered, and the filtrate was concentrated to give the title compound (122 mg) as a white solid. The obtained solid was crystallized from acetonitrile, diisopropyl ether and hexane to give a white solid.

後処理

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-a4a40a36f1a54a09a4fbcf0fdac744a0
出典データセット
uspto-grants-2014_12
特許番号
US08916551B2

反応ノート

読み込み中…