Sodium borohydride → 4-(4-Bromo-2-chloro-phenoxy)-benzylamine

HRID 1406360ノート

反応式

HRID 1406360 の反応式
[Br:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][C:7]2[CH:15]=[CH:14][C:10]([CH:11]=[N:12]O)=[CH:9][CH:8]=2)=[C:4]([Cl:18])[CH:3]=1.[BH4-].[Na+]>CO.O.O.O.O.O.O.[Ni](Cl)Cl>[Br:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][C:7]2[CH:15]=[CH:14][C:10]([CH2:11][NH2:12])=[CH:9][CH:8]=2)=[C:4]([Cl:18])[CH:3]=1

参加物

5

反応物 2

HCID 4311764Sodium borohydrideHCID 866588184-(4-Bromo-2-chloro-phenoxy)-benzaldehyde-oxime

生成物 1

HCID 289663904-(4-Bromo-2-chloro-phenoxy)-benzylamine

試薬・触媒・溶媒 2

HCID 11791229Dichloronickel;hexahydrate触媒HCID 887Methanol溶媒

実験手順

18 mg (0.06 mmol) of 4-(4-bromo-2-chloro-phenoxy)-benzaldehyde-oxime was dissolved in 2 mL methanol, then 37 mg (0.15 mmol) of nickel(II)chloride hexahydrate and 21 mg (0.56 mmol) of sodium borohydride were slowly added. The reaction mixture was stirred overnight at RT and then purified by chromatography (reversed phase).

後処理

  1. custompurified by chromatography (reversed phase)

出典と根拠

ORDレコード
ord-3ccc45aa815c4eaa9de64efc9b27ebdf
出典データセット
uspto-grants-2014_12
特許番号
US08916589B2

反応ノート

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