Pyridine → HCID 71680611、化合物

HRID 1406572ノート

反応式

HRID 1406572 の反応式
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([S:11](Cl)(=[O:13])=[O:12])=[CH:7][C:6]=1[F:15])([CH3:4])([CH3:3])[CH3:2].Br[C:17]1[CH:18]=[CH:19][C:20]([N:27]2[C:31]([NH2:32])=[CH:30][C:29]([CH3:33])=[N:28]2)=[C:21]2[C:26]=1[N:25]=[CH:24][CH:23]=[CH:22]2.[N:34]1C=CC=CC=1>>[NH2:34][C:17]1[CH:18]=[CH:19][C:20]([N:27]2[C:31]([NH:32][S:11]([C:8]3[CH:9]=[CH:10][C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])=[C:6]([F:15])[CH:7]=3)(=[O:13])=[O:12])=[CH:30][C:29]([CH3:33])=[N:28]2)=[C:21]2[C:26]=1[N:25]=[CH:24][CH:23]=[CH:22]2

参加物

4

反応物 3

HCID 1049PyridineHCID 848039791452184-05-2HCID 86694542HCID 86694542、化合物

生成物 1

HCID 71680611HCID 71680611、化合物収率 62%

反応条件

温度
80 °C

実験手順

A stirring mixture of 4-t-butyl-3-fluorobenzene-1-sulfonyl chloride (prepared from Example 27 step c, 1.1 g, 4.2 mmol) and 1-(8-bromoquinolin-5-yl)-3-methyl-1H-pyrazol-5-amine (0.97 g, 3.2 mmol) in pyridine (5 mL) was heated at 80° C. for 15 h. After cooling to room temperature, the reaction mixture was concentrated in vacuo. The crude solid was recrystallized from hot ethanol (5 mL) and the resulting solid was collected by filtration to give the desired compound (0.10 g, 0.19 mmol, 62%).

後処理

  1. temperatureAfter cooling to room temperature
  2. concentrationthe reaction mixture was concentrated in vacuo
  3. customThe crude solid was recrystallized from hot ethanol (5 mL)
  4. filtrationthe resulting solid was collected by filtration

出典と根拠

ORDレコード
ord-1ab956b73b0a4aada030e5f198b1a4c9
出典データセット
uspto-grants-2014_12
特許番号
US08916601B2

反応ノート

読み込み中…