tert-Butanol → 4-(1-benzyl-1H-1,2,3-triazol-4-yl)-2-(2-nitro-5-(piperidin-1-yl)phenyl)pyridine

HRID 1408058ノート

反応式

HRID 1408058 の反応式
[C:1]([C:3]1[CH:8]=[CH:7][N:6]=[C:5]([C:9]2[CH:14]=[C:13]([N:15]3[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]3)[CH:12]=[CH:11][C:10]=2[N+:21]([O-:23])=[O:22])[CH:4]=1)#[CH:2].[CH2:24]([N:31]=[N+:32]=[N-:33])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1.O=C1O[C@H]([C@H](CO)O)C([O-])=C1O.[Na+].C(O)(C)(C)C>[O-]S([O-])(=O)=O.[Cu+2].O>[CH2:24]([N:31]1[CH:2]=[C:1]([C:3]2[CH:8]=[CH:7][N:6]=[C:5]([C:9]3[CH:14]=[C:13]([N:15]4[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20]4)[CH:12]=[CH:11][C:10]=3[N+:21]([O-:23])=[O:22])[CH:4]=2)[N:33]=[N:32]1)[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1

参加物

7

反応物 4

HCID 6386tert-ButanolHCID 12152Benzyl azideHCID 23667548Sodium AscorbateHCID 867059454-Ethynyl-2-(2-nitro-5-(piperidin-1-yl)phenyl)pyridine

生成物 1

HCID 867059464-(1-benzyl-1H-1,2,3-triazol-4-yl)-2-(2-nitro-5-(piperidin-1-yl)phenyl)pyridine

試薬・触媒・溶媒 2

HCID 24462Copper Sulfate触媒HCID 962Water溶媒

実験手順

A solution of 50 mg of 4-ethynyl-2-(2-nitro-5-(piperidin-1-yl)phenyl)pyridine, 20 μL of benzyl azide, 16.3 μL of 1 M aqueous sodium ascorbate solution, 5.4 μL of 0.3 M CuSO4 solution, 326 μL of tert-butanol, and 326 μL of water was stirred for 2 days and then the solvent was evaporated at reduced pressure. The residue was dissolved in dichloromethane. The solution was washed with water and dried. The solvent was evaporated at reduced pressure and the residue was chromatographed on silica gel eluting with a 0% to 4% gradient of methanol in dichloromethane. The process yielded 22 mg of product.

後処理

  1. customthe solvent was evaporated at reduced pressure
  2. dissolutionThe residue was dissolved in dichloromethane
  3. washThe solution was washed with water
  4. customdried
  5. customThe solvent was evaporated at reduced pressure
  6. customthe residue was chromatographed on silica gel eluting with a 0% to 4% gradient of methanol in dichloromethane

出典と根拠

ORDレコード
ord-adb7d2cc278840a6a38e5c16ae5f4780
出典データセット
uspto-grants-2014_12
特許番号
US08916569B2

反応ノート

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