Hydrochloric Acid → 3-Isopropylbenzylamine Hydrochloride

HRID 14083

反応式

HRID 14083 の反応式
[C:1]([C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[C:7]#[N:8])([CH3:3])=[CH2:2].[ClH:12]>C(O)C.C(O)(=O)C.CO.C(OCC)C.[Pd]>[ClH:12].[CH:1]([C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[CH2:7][NH2:8])([CH3:3])[CH3:2]

参加物

8

反応物 2

HCID 313Hydrochloric AcidHCID 121802503-Isopropenylbenzonitrile

生成物 1

HCID 210858343-Isopropylbenzylamine Hydrochloride

試薬・触媒・溶媒 5

HCID 23938Palladium触媒HCID 176Acetic Acid溶媒HCID 702Ethanol溶媒HCID 887Methanol溶媒HCID 3283Diethyl Ether溶媒

実験手順

A solution of 3-isopropenylbenzonitrile (6.0 g, 41.9 mmol) and 10% Pd/C (600 mg) in ethanol (65 mL) and acetic acid (2.4 mL) is degassed with nitrogen for 15 min, and shaken under an atmosphere of hydrogen at 50 psi for 12 h. The reaction mixture is filtered through diatomaceous earth and concentrated under reduced pressure to provide an oil. The oil is dissolved in methanol (5 mL) and hydrochloric acid (15 mL of a 1 M solution in diethyl ether) is added. The resulting precipitate is collected by filtration to provide the title compound. APCI MS m/z 149 [M+H]+.

後処理

  1. filtrationThe reaction mixture is filtered through diatomaceous earth
  2. concentrationconcentrated under reduced pressure
  3. customto provide an oil
  4. filtrationThe resulting precipitate is collected by filtration

出典と根拠

ORDレコード
ord-0e40f910a0c8435fa67987e268e28a55
出典データセット
uspto-grants-2010_06
特許番号
US07727997B2

関連ノート

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